Prelude Therapeutics INC

Market Movers (8-K)

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NASDAQ
Prelude Therapeutics announced its second quarter 2026 financial results, highlighting progress in its oncology pipeline and a cash runway extending into Q2 2028.
NASDAQ
Prelude Therapeutics Incorporated announced the results of its 2026 Annual Meeting of Stockholders, including the election of directors and ratification of its independent auditor.
NASDAQ
Prelude Therapeutics reported Q1 2026 financial results, highlighting progress in its PRT12396 and PRT13722 programs, and extended cash runway into Q2 2028.
Capital raise
NASDAQ
Prelude Therapeutics announced new preclinical data for its lead candidate, PRT13722, a selective KAT6A degrader, showing potential for differentiated efficacy and safety in HR+/HER2- breast cancer.
NASDAQ
Prelude Therapeutics Incorporated announced the appointment of Dr. Charles Morris as its new Chief Medical Officer, effective April 20, 2026, bringing extensive oncology drug development experience to the company.
NASDAQ
Prelude Therapeutics Inc. has filed a prospectus supplement to offer and sell up to an additional $25.0 million of its common stock through an at-the-market facility.
Capital raise

Quarterly Earnings (10-Q)

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NASDAQ
Prelude Therapeutics Incorporated announced its financial results for the second quarter ended June 30, 2026, highlighting progress in its oncology pipeline and a significant capital raise.
Worse than expected
Capital raise
NASDAQ
Prelude Therapeutics Inc. reported its first-quarter 2026 financial results, highlighting progress in its oncology pipeline and a significant cash position following a recent offering.
Capital raise
NASDAQ
Prelude Therapeutics reported a reduced net loss for Q3 2025, secured $60 million in new capital from Incyte, and strategically paused its SMARCA2 degrader program to focus on JAK2 and KAT6A, while acknowledging substantial doubt about its going concern ability.
Delay expected
Worse than expected
Capital raise
NASDAQ
Prelude Therapeutics reported continued operating losses and a going concern warning, alongside progress in its oncology pipeline and a Nasdaq minimum bid price deficiency.
Capital raise
Worse than expected
NASDAQ
Prelude Therapeutics reports a net loss of $32.1 million for Q1 2025 and expresses substantial doubt about its ability to continue as a going concern without additional funding.
Capital raise
Worse than expected
NASDAQ
Prelude Therapeutics reported a net loss of $32.3 million for the third quarter of 2024, while highlighting progress in its clinical programs and a new licensing agreement.
Worse than expected
Capital raise

Annual Reports (10-K)

NASDAQ
Prelude Therapeutics advances its clinical-stage precision oncology pipeline, showcasing positive Phase 1 data for PRT3789 and initiating a Phase 2 trial, while strategically partnering to expand its ADC capabilities.
Capital raise
NASDAQ
Prelude Therapeutics updates its registration rights agreement and files its annual 10-K report, detailing its financial status and clinical development pipeline.
Capital raise
Worse than expected

Insider Trading (Form 4)

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NASDAQ
Baker Bros. Advisors LP, a significant holder and director-affiliated entity, has acquired 38,000 non-qualified stock options for Prelude Therapeutics Inc. (PRLD) with a strike price of $3.94.
NASDAQ
Director Katina Dorton was granted 38,000 stock options in Prelude Therapeutics Inc. as part of a standard equity compensation package.
NASDAQ
Director Martin Babler was granted 38,000 stock options in Prelude Therapeutics Inc. as part of an equity compensation award.
NASDAQ
Director David P. Bonita was granted 38,000 stock options in Prelude Therapeutics Inc. as part of a standard compensation arrangement.
NASDAQ
Director Victor Sandor was granted 38,000 stock options in Prelude Therapeutics Inc. as part of an equity compensation award.
NASDAQ
Paul A. Friedman, a Director at Prelude Therapeutics Inc., has acquired stock options granting the right to buy 38,000 shares.

Proxy Statements (Def-14A)

NASDAQ
Prelude Therapeutics Inc. has filed a definitive proxy statement with the SEC.
NASDAQ
Prelude Therapeutics is asking stockholders to approve an amendment to its restated certificate of incorporation to increase the number of authorized non-voting common shares, providing greater flexibility for future business needs.
Capital raise
NASDAQ
Prelude Therapeutics Incorporated files a definitive proxy statement with the Securities and Exchange Commission (SEC) pertaining to Section 14(a) of the Securities Exchange Act of 1934.
NASDAQ
Prelude Therapeutics will hold its 2024 Annual Meeting of Stockholders virtually on June 14, 2024, to elect directors and ratify the appointment of its independent accounting firm.

Schedule 13D - Activist Investments

NASDAQ
OrbiMed Advisors reports a change in beneficial ownership of Prelude Therapeutics following a recent public offering.
Capital raise
NASDAQ
Baker Bros. Advisors reported an increased beneficial ownership of 15.5% in Prelude Therapeutics following a recent public offering.
Capital raise
NASDAQ
Baker Bros. Advisors has filed an amendment to its Schedule 13D, confirming its 23.5% beneficial ownership in Prelude Therapeutics Inc. and announcing a change in its board representation with Dr. Paul C. Scherer joining and Julian C. Baker stepping down.
Capital raise

Schedule 13G - Passive Investments

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NASDAQ
Soleus Capital Management L.P. and affiliated entities report beneficial ownership of 5.2% of Prelude Therapeutics Inc. common stock as of April 21, 2026.
NASDAQ
RA Capital Management and associated parties have filed a Schedule 13G reporting a 9.9% beneficial ownership stake in Prelude Therapeutics Incorporated.
Capital raise
NASDAQ
Krishna Vaddi, a key insider, has reported a beneficial ownership of 13.15% in Prelude Therapeutics Inc., totaling 6,745,647 shares.
NASDAQ
Incyte Corporation has reported a 9.9% beneficial ownership stake in Prelude Therapeutics, Inc., primarily through convertible non-voting common stock.
Capital raise
NASDAQ
Krishna Vaddi, a key individual associated with Prelude Therapeutics Inc., has filed an amended Schedule 13G, disclosing a beneficial ownership of 13.8% of the company's common stock as of March 31, 2025.
NASDAQ
Krishna Vaddi, an individual, has reported a 9.5% beneficial ownership stake in Prelude Therapeutics Inc., totaling 5,489,130 shares as of December 31, 2024.